The 2nd Beru Khyentse was born in central Tibet in 1947 and, as a young monk, was recognised and enthroned by the 16th Karmapa. At the age of 13 he led his monks and lay devotees from his monastery in Nangchen, out of Tibet, and established a community including monastery and retreat centre for them in Mainpat, India.

Rinpoche completed extensive studies in Buddhist philosophy and training in Vajrayana rituals, receiving instruction from many Lamas including Dzongsar Khenpo Chimey Rinpoche, Kyabje Kalu Rinpoche, the 16th Gyalway Karmapa, Khunu Rinpoche, His Holiness Sakya Trizin and Dilgo Khyentse Rinpoche. After completing the traditional four-year retreat in the Karma Kamtsang tradition, Rinpoche established monasteries in Bodh Gaya and Kathmandu and the Nangchen monastery, nunnery, institute and 3-yr retreat centre in Tibet. Rinpoche rebuilt the Sakya monastery, Nyenthang Treshi gang, near his birthplace in Tibet and founded the Tharjay Charitable Foundation to sponsor bridges, schools, clinics and medical treatment for the nomads of east Tibet.